High Flavonoid-content Syrup

Flavita LifeMAX

254.000Ft

(700 €)

Special selection made of fruits, flowers, herbs, spices, roots, sprouts, seeds and their extracts. The product is enriched with high purity resveratrol extracted from natures source, and silymarin, myricetin, anthocyanidin, quercetin, apigenin, hesperidin, luteolin, kaempferol and glabridin flavonoid fractions.

Availability: In stock

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Assumed benefits of consuming flavonoids

In nature, more than 6000 flavonoids exist that have several functions as secondary metabolites of plants and fungi, from giving the color of the flowers/fruit to the protection against UV radiation, or pathogens.

Flavonoids, like vitamins, can affect the organisms that consume plants and fungi. Flavonoids of potential importance to humans can be ranked according to 2 criteria of a scientific base.

On the one hand getting into the body and influencing the metabolism, the flavonoids with significant health care or health-enhancing capabilities are more interesting, since they can be used in alternative medicine. On the other hand, those flavonoids got in focus that are in such a large amount in our foods, so after absorption they can appear in the blood in physiologically accountable concentrations.

Unfortunately, this second criterion does not apply to all flavonoids, because some flavonoids are less common or more sensitive to different food processing technologies. In addition, environmental factors such as temperature and duration of sunshine, or the ripeness of vegetables and fruits also affect the flavonoid composition.

In case of the existence of the disease, the further intake of vitamins, and flavonoids considered important in addition to diet should also be considered in order to support the healing process with adequate quality and quantity of flavonoids. This may be particularly important in the case of anorexia, when food intake is already lower.

The best example for the benefit of extra flavonoid-intake is associated with the blood vessel protection effect of flavonoids. Albert Szent-Györgyi, the Hungarian Nobel Laureate, supported the ‘vitamin C treatment’ of scurvy patients with flavonoids. Instead of prescribing a large amount of vegetable and fruit consumption, he gave flavonoid fractions successfully extracted from lemon juice and Hungarian red pepper, along with vitamin C also extract from these plants.

Patients taking both vitamin and flavonoids recovered more quickly from scurvy than those treated with vitamin C alone. The increase in efficiency was due to the fact that the flavonoid fraction, in synergy with the effect of vitamin C, was more effective in reducing capillary fragmentation and leakage.

In the more than 80 years since the discovery of Albert Szent-Györgyi, many other beneficial biological functions have been successfully linked to flavonoids. Flavonoids are general antioxidants, are able to neutralize free radicals, such as reactive oxygen radicals formed under oxidative stress, and may also have anti-inflammatory effects. Thus, they can also contribute to the prevention of the development of cancer and various cardiovascular diseases, such as atherosclerosis, as well as to support their treatment.

In addition, they can be effective in reducing the risk and slowing down the course of neurodegenerative diseases, as evidenced by a number of studies on Alzheimer's disease and other dementias. Flavonoids also function as anti-aging components, so they can contribute to beauty.

In summary, in order to the listed beneficial effects to be achieved a certain level of flavonoids must be present in the blood plasma, which - in many cases – can be achieved only by flavonoid fractions enriched diet, especially in the case of supporting treatments.

Science behind

High-dose bioflavonoids - Examples from professional literature

In the case of excellent healthcare and support of disease management effect of bioflavonoids, usually the dose-response relationship prevails. According to this, a small amount achieves a weaker effect, a large amount achieves a more significant effect. It is also possible that certain positive effects only occur or are significant if a really large dose of flavonoids gets in the body, which can ensure a higher plasma concentration. Such a case may also occur when sufficient dose of flavonoids may be administered in the body only with special attention, which should then be in the form of dietary supplements.

The inverse association between flavonoid consumption and cancer-related deaths is confirmed by a number of observations. A 2019 study in Denmark involving 56,000 people showed that the risk of someone dying from cancer was significantly reduced as the flavonoid consumption increased. The correlation was significant up to a daily intake of 500 mg, so based on this, a minimum total daily intake of 500 mg of flavonoids can be recommended for prevention.

An earlier study in 2004 showed that people with ovarian cancer had a better chance of survival if they drank green tea every day, the beneficial effect of which was dose-dependent as well: those who drank more than 1 cup a day had the most spectacular risk reduction. Catechins such as EGCG in green tea are the larger amounts of flavonoids. A similar evidence showed in another study where patients who previously had been treated for breast were monitored. During an average of 4 years of observation, in proportion to the consumption of soy the survival was favorable, which was partially associated with soybean isoflavonoids. According to the results, at least a daily 40 mg of isoflavonoid intake could have a significant and protective effect.

The high death rate resulted from cancerous diseases is due to therapy-resistance when cancer cells do not (or just at the beginning of treatment) respond to chemotherapeutic agents, and therefore are not destroyed. Unfortunately, there are cases when the tumor cells become resistant not only against the applied agents, but a general resistance mechanism is also activated.

This multiple drug resistance, or multidrug-resistance is surrounded by intensive research, one segment relates to flavonoids. Many scientific publications have shown that many natural flavonoids are effective in killing isolated, multidrug-resistant cancer cells. Certain flavonoids targeted especially the resistant cancer cells. There are more and more examples of activity being observed in cancer models of animal experiments, when a chemotherapeutic agent becomes more effective in combination with flavonoids. In any case, further confirmatory experiments and clinical observations are still expected.

Sources:

  • Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort. Nat Commun. 2019; 10: 3651.
  • Green Tea Consumption Enhances Survival of Epithelial Ovarian Cancer. Int J Cancer. 2004; 112(3):465-9.
  • Soy Food Intake and Breast Cancer Survival. JAMA. 2009; 302(22): 2437–2443.
  • Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance. Chem Rev. 2014; 114(11):5753-74.
  • Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids. Front Oncol. 2019; 9:487.

Flavonoids can contribute to cardiovascular system protection in a dose-related manner. The risk of both the need for hospitalization for arteriosclerosis and the risk of dying from cardiovascular disease showed a decreasing trend with increasing flavonoid intake, showed in two large Danish group studies. According to the publications, the total daily flavonoid intake should be increased above 500 mg, and within this, the most important flavonoids, such as cempferol and quercetin, should be increased to at least 10 mg and 25 mg per day.

The quercetin helped the relaxation of the coronary arteries in a dose-dependent manner (higher doses, greater relaxation), the long-term effect of treatment influenced the structural and functional remodeling of vascular wall associated with aging in positive way in the rat model experiments.

Sources:

  • Associations between habitual flavonoid intake and hospital admissions for atherosclerotic cardiovascular disease: a prospective cohort study. Lancet Planet Health. 2019; 3(11):e450-e459.
  • Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort. Nat Commun. 2019; 10: 3651.
  • Chronic Administration of Quercetin Induces Biomechanical and Pharmacological Remodeling in the Rat Coronary Arteries. Physiol Res. 2017; 66(4):591-599.
  • Quantitative Analysis of Vasodilatory Action of Quercetin on Intramural Coronary Resistance Arteries of the Rat In Vitro. PLoS One. 2014; 9(8): e105587.

Substances of natural origin are becoming more popular in cosmetics. Anti-aging effects, skin brightening, UV-protection and maintaining the elasticity of the skin are also among the possible uses.

In an experiment on mice, the animals were fed two different extracts from the skin of red grapes. One extract contained a mixture of flavonoids, mainly of the anthocyanin type, but resveratrol was also present, while the other fraction contained only resveratrol. Both were able to restrain the formation of wrinkles induced by UV-radiation.

In another experiment, hamsters were fed high-fat foods. Animals that also received hibiscus extract had markedly reduced symptoms of obesity, whether it was an increase in cholesterol, blood sugar control, or adipose tissue weight. In addition, by increasing the consumption of hibiscus extract, the positive effects also intensified.

The other polyphenol-containing extract of hibiscus also inhibited the formation of new fat cells, thus acting against obesity. Similar results were found by an experiment conducted on mice, where the large amount of kaempferol consumption reduced weight-gain, hepatic steatosis, high blood sugar and cholesterol levels due to high-fat diet.

Sources:

  • Depigmentation and Anti-aging Treatment by Natural Molecules. Curr Pharm Des. 2019; 25(20):2292-2312.
  • Grape Peel Extract and Resveratrol Inhibit Wrinkle Formation in Mice Model Through Activation of Nrf2/HO-1 Signaling Pathway. J Food Sci. 2019; 84(6):1600-1608.
  • Polyphenolic Extract From Hibiscus Sabdariffa Reduces Body Fat by Inhibiting Hepatic Lipogenesis and Preadipocyte Adipogenesis. Food Funct. 2016; 7(1):171-82.
  • Preventive Effects of Kaempferol on High-Fat Diet-Induced Obesity Complications in C57BL/6 Mice. Biomed Res Int. 2020; 2020:4532482.
  • Tumors
  • Cardiovascular system
  • Beauty

The inverse association between flavonoid consumption and cancer-related deaths is confirmed by a number of observations. A 2019 study in Denmark involving 56,000 people showed that the risk of someone dying from cancer was significantly reduced as the flavonoid consumption increased. The correlation was significant up to a daily intake of 500 mg, so based on this, a minimum total daily intake of 500 mg of flavonoids can be recommended for prevention.

An earlier study in 2004 showed that people with ovarian cancer had a better chance of survival if they drank green tea every day, the beneficial effect of which was dose-dependent as well: those who drank more than 1 cup a day had the most spectacular risk reduction. Catechins such as EGCG in green tea are the larger amounts of flavonoids. A similar evidence showed in another study where patients who previously had been treated for breast were monitored. During an average of 4 years of observation, in proportion to the consumption of soy the survival was favorable, which was partially associated with soybean isoflavonoids. According to the results, at least a daily 40 mg of isoflavonoid intake could have a significant and protective effect.

The high death rate resulted from cancerous diseases is due to therapy-resistance when cancer cells do not (or just at the beginning of treatment) respond to chemotherapeutic agents, and therefore are not destroyed. Unfortunately, there are cases when the tumor cells become resistant not only against the applied agents, but a general resistance mechanism is also activated.

This multiple drug resistance, or multidrug-resistance is surrounded by intensive research, one segment relates to flavonoids. Many scientific publications have shown that many natural flavonoids are effective in killing isolated, multidrug-resistant cancer cells. Certain flavonoids targeted especially the resistant cancer cells. There are more and more examples of activity being observed in cancer models of animal experiments, when a chemotherapeutic agent becomes more effective in combination with flavonoids. In any case, further confirmatory experiments and clinical observations are still expected.

Sources:

  • Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort. Nat Commun. 2019; 10: 3651.
  • Green Tea Consumption Enhances Survival of Epithelial Ovarian Cancer. Int J Cancer. 2004; 112(3):465-9.
  • Soy Food Intake and Breast Cancer Survival. JAMA. 2009; 302(22): 2437–2443.
  • Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance. Chem Rev. 2014; 114(11):5753-74.
  • Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids. Front Oncol. 2019; 9:487.

Flavonoids can contribute to cardiovascular system protection in a dose-related manner. The risk of both the need for hospitalization for arteriosclerosis and the risk of dying from cardiovascular disease showed a decreasing trend with increasing flavonoid intake, showed in two large Danish group studies. According to the publications, the total daily flavonoid intake should be increased above 500 mg, and within this, the most important flavonoids, such as cempferol and quercetin, should be increased to at least 10 mg and 25 mg per day.

The quercetin helped the relaxation of the coronary arteries in a dose-dependent manner (higher doses, greater relaxation), the long-term effect of treatment influenced the structural and functional remodeling of vascular wall associated with aging in positive way in the rat model experiments.

Sources:

  • Associations between habitual flavonoid intake and hospital admissions for atherosclerotic cardiovascular disease: a prospective cohort study. Lancet Planet Health. 2019; 3(11):e450-e459.
  • Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort. Nat Commun. 2019; 10: 3651.
  • Chronic Administration of Quercetin Induces Biomechanical and Pharmacological Remodeling in the Rat Coronary Arteries. Physiol Res. 2017; 66(4):591-599.
  • Quantitative Analysis of Vasodilatory Action of Quercetin on Intramural Coronary Resistance Arteries of the Rat In Vitro. PLoS One. 2014; 9(8): e105587.

Substances of natural origin are becoming more popular in cosmetics. Anti-aging effects, skin brightening, UV-protection and maintaining the elasticity of the skin are also among the possible uses.

In an experiment on mice, the animals were fed two different extracts from the skin of red grapes. One extract contained a mixture of flavonoids, mainly of the anthocyanin type, but resveratrol was also present, while the other fraction contained only resveratrol. Both were able to restrain the formation of wrinkles induced by UV-radiation.

In another experiment, hamsters were fed high-fat foods. Animals that also received hibiscus extract had markedly reduced symptoms of obesity, whether it was an increase in cholesterol, blood sugar control, or adipose tissue weight. In addition, by increasing the consumption of hibiscus extract, the positive effects also intensified.

The other polyphenol-containing extract of hibiscus also inhibited the formation of new fat cells, thus acting against obesity. Similar results were found by an experiment conducted on mice, where the large amount of kaempferol consumption reduced weight-gain, hepatic steatosis, high blood sugar and cholesterol levels due to high-fat diet.

Sources:

  • Depigmentation and Anti-aging Treatment by Natural Molecules. Curr Pharm Des. 2019; 25(20):2292-2312.
  • Grape Peel Extract and Resveratrol Inhibit Wrinkle Formation in Mice Model Through Activation of Nrf2/HO-1 Signaling Pathway. J Food Sci. 2019; 84(6):1600-1608.
  • Polyphenolic Extract From Hibiscus Sabdariffa Reduces Body Fat by Inhibiting Hepatic Lipogenesis and Preadipocyte Adipogenesis. Food Funct. 2016; 7(1):171-82.
  • Preventive Effects of Kaempferol on High-Fat Diet-Induced Obesity Complications in C57BL/6 Mice. Biomed Res Int. 2020; 2020:4532482.

Flavonoids

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Ingredients
  • Active Ingredients
  • Ingredients
Active ingredients in a daily dosein 10 mlin 20 mlin 100 ml
Energy content306,43 kJ (70,38 kcal)612,86 kJ (140,76 kcal)3064,3 kJ (703,8 kcal)
Protein (g)0,380,763,79
Carbohydrates (g)1,1452,2911,45
Sugar (g)0,981,969,75
Fat (g)0,30,63,05
Saturated fatty acid (g)0,30,63,05
Fibers (g)0,61,26,05
Sodium (g)0,010,020,1
Silymarin 60% (g)0,531,065,3
Myricetin 80% (g)0,350,73,5
Quercetin 98% (g)0,220,442,15
Resveratrol 98% (g)0,180,361,75
Apigenin 98% (g)0,130,261,3
Hesperidin 90% (g)0,120,241,2
Glabridin 40% (g)0,1150,231,115
Luteolin 98% (g)0,070,140,65
Kaempferol 98% (g)0,050,10,45

Filtered, purified water, peppermint, aniseed grist, Sylimarin, Myricetin, Anthocyanidin, Quercetin, Resveratrol, Apigenin, Hesperidin, Glabridin, cacao pulver, Luteolin, Kaempferol and many additional fruits, flowers, seeds, herbs, condiments, roots, leaves (see list on the side of the package) with significant polyphenol/flavonoid content (12000 mg/100 g). Sweetener: Stevia rebaudiana leaf extract (Steviol-glycosid 95%, E960).

Dosage

Suggested dose

See suggested dosage. 1) 10ml daily, after breakfast. 2) 15-25 ml divided: after breakfast and lunch.
Kiszerelés

Packaging

Packaging

250 ml (Net. vol)
Eltarthatóság

Shelf life

Best before

For 3 years from production. The date of manufacture and expiry are indicated on the packaging.
Tárolás

Storage

Storage

Avoid direct sunlight; in a dry, cool place.
Notice

Daily dose should not be exceeded!

- Dietary supplements are not substitutes for a balanced diet.
- Dietary supplements are not medicines, nor substitutes for medicines!
- The desired volume can be measured with the measuring cap in the product box.
- Shake well before use.
- Keep in mouth for 2-3 minutes before swallowing, for better absorption.
- Once opened, store refrigerated and use up within 30 days.
- The product is free of preservatives, to avoid premature deterioration, do not drink directly from the bottle.
- Do not use the product for 24 hours before and after chemotherapy!
- Not recommended in case of cirrhosis or kidney failure;
- Keep out of the reach of children.

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Flavita®

Bioflavonoid Complex

Flavita Family

Products of our FLAVITA product family contain concentrated flavonoids and other valuable plant antioxidants in the form of capsules or syrups.