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Hyaluronic Acid and Collagen

Hyaluron Collagen

NAVITA Hyaluron + Collagen contains hyaluronic acid and hydrolyzed collagen extracted from Norwegian salmon skin, which have been combined with bioflavonoids and other antioxidants.

15.240Ft

(45 €)

Availability: Only 4 left in stock

The role of collagen and hyaluronic acid in beauty

Beauty has always been an important aspect of social judgment. While e.g. opinions about the ideal physique are more divided, the healthy appearance of our hair, teeth and skin is uniformly a symbol of youth. Nowadays, teeth can be replaced, hair implants are possible, and with the help of plastic surgery, the shapes that are considered perfect have become available, the only thing we can’t replace is our skin.

Skin is the primary and most authentic mirror of our age. Tight, healthy skin has high levels of collagen and hyaluronic acid - the former provides a framework for the skin that protects against sagging, while the latter has a water-retaining function, helps keep the skin smooth and increases its elasticity. Aging is accompanied by a deterioration in the condition of the skin, because over the years, our body is no longer able to produce either collagen or hyaluronic acid with sufficient efficiency. Over the age of 30 collagen content of the skin may decrease up to 1% per year, and because the 90% of the dermis is collagen, the skin is thinning, wrinkling and sagging. To compensate for this, external replacement is needed.

A common goal of anti-aging skin care products is to promote or replace collagen production. However, the effectiveness of the product is also significantly affected by the technology used or the source of collagen. From a technological point of view, as a dietary supplement, the so-called hydrolyzed collagen is most suitable. The collagen is then broken down into smaller peptides and building blocks by enzymatic digestion to promote absorption and thus a beneficial effect.

Collagen extracted from cattle, pigs and fish skins has proven to be suitable and widely available for replenishing skin collagen. Bovine and porcine collagen are generally less well absorbed, less efficiently utilized, and there is a risk that if animals are treated with hormone, it will enrich their skin and may be present in the product. In addition, bovine collagen may pose an additional health risk with the appearance of mad cow disease.

The development and research of collagen peptides from marine fish is growing most dynamically in the food supplement market. They are efficiently absorbed through the intestines, show homology (similarity) to human collagen, making them safer to use, and show many bioactivities.

Their anti-aging effect is mainly through the support of skin and bone health, but collagen hydrolysates may also have antioxidant properties and antihypertensive activity. Collagen peptides penetrated into the skin stimulates the collagen and elastin synthesis of the skin cells (the fibroblasts), and may increase the production of hyaluronic acid, which also may require additional hyaluronic acid in excess of the diet intake.

Collagen synthesis and flavonoids

Importantly, a side effect of intense collagen synthesis has also been observed: increased metabolism of fibroblasts leads to low levels of oxidative stress, which may limit the beneficial effects of collagen peptides.

However, to counteract this, some antioxidants, e.g. of polyphenols and flavonoids, proved to be excellent, so it is worth providing its intake. In general, dietary intake of vitamins, plant polyphenols, fatty acids, certain proteins, essential amino acids and trace elements (e.g. selenium) also have a beneficial effect on the appearance and health of the skin.

Hyaluron + CollagenHyaluron + Collagen
Science behind

Scientifically observed effects of collagen and hyaluronic acid intake

The effects of fish skin-derived collagen and hyaluronic acid dietary supplements have been shown in human clinical trials as early as 1-3 months, and the results of a 2-3-month course of treatment remained visible for months.

During the course of treatment, the density of collagen in the skin generally increased, while the fragmentation of the dermal collagen network decreased. The elasticity and hydration of the skin increased; the depth of wrinkles decreased. The premature aging of skin cells has slowed or stopped.

According to an Italian study, in women - age of 50, taking a product also containing hyaluronic acid reduced the depth of wrinkles in both the eyebrows (glabella), around the eyes, and around the mouth, and increased skin hydration and elasticity.

The elasticity of the skin was also improved by a collagen extract from sea fish combined with antioxidants (e.g. grape seed extract, luteolin flavonoid) without the oxidative stress associated with intense collagen synthesis burdening the body. Taking a collagen hydrolysate from a freshwater fish (Asian shark catfish) also improved skin hydration, elasticity, and reduced wrinkling in 40-60-year-old women.

When hairless mice were exposed to ultraviolet radiation to test the skin aging effect of sunlight, better results were measured in a group of animals consuming collagen extracted from fish skin. Collagen consumption resulted in higher skin hydration, and wrinkles did not appear as markedly as in mice that did not consume collagen. Further tests could reveal that for this the increased synthesis of hyaluronic acid was responsible.

Sources:

  • Randomized, Placebo-controlled Study of a Nutraceutical Based on Hyaluronic Acid, L-carnosine, and Methylsulfonylmethane in Facial Skin Aesthetics and Well-being. J Clin Aesthet Dermatol. 2019; 12(4):40-45.
  • Skin Anti-aging and Systemic Redox Effects of Supplementation with Marine Collagen Peptides and Plant-Derived Antioxidants: A Single-Blind Case-Control Clinical Study. Oxid Med Cell Longev. 2016; 2016:4389410.
  • Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2018; 10(7): 826.
  • Oral Intake of Collagen Peptide Attenuates Ultraviolet B Irradiation-Induced Skin Dehydration In Vivo by Regulating Hyaluronic Acid Synthesis. Int J Mol Sci. 2018; 19(11). pii: E3551.

According to a Chinese study of deep-sea fish collagen peptides derived from supporting the treatment of diabetes and high blood pressure. During the 3-month experiment, insulin sensitivity index of collagen users increased, total blood cholesterol and ‘bad’’ cholesterol (low-density lipoprotein) decreased, blood pressure decreased as well as the creatinine level that concluded in improved renal function.

Source:

  • Therapeutic effects of marine collagen peptides on Chinese patients with type 2 diabetes mellitus and primary hypertension. Am J Med Sci. 2010; 340(5):360-6.

Dry eyes are a modern-day folk disease that can lead to eye inflammation or even visual impairment. According to a Korean clinical study, regular intake of hyaluronic acid reduced the symptoms of dry eye syndrome, subjects reported relief of eye irritation, and studies confirmed regeneration of the cornea of the eye.

Source:

  • Oral Hyaluronic Acid Supplementation for the Treatment of Dry Eye Disease: A Pilot Study. J Ophthalmol. 2019; 2019:5491626.
  • Skin anti-aging
  • Diabetes and hypertension
  • Dry eye

According to an Italian study, in women - age of 50, taking a product also containing hyaluronic acid reduced the depth of wrinkles in both the eyebrows (glabella), around the eyes, and around the mouth, and increased skin hydration and elasticity.

The elasticity of the skin was also improved by a collagen extract from sea fish combined with antioxidants (e.g. grape seed extract, luteolin flavonoid) without the oxidative stress associated with intense collagen synthesis burdening the body. Taking a collagen hydrolysate from a freshwater fish (Asian shark catfish) also improved skin hydration, elasticity, and reduced wrinkling in 40-60-year-old women.

When hairless mice were exposed to ultraviolet radiation to test the skin aging effect of sunlight, better results were measured in a group of animals consuming collagen extracted from fish skin. Collagen consumption resulted in higher skin hydration, and wrinkles did not appear as markedly as in mice that did not consume collagen. Further tests could reveal that for this the increased synthesis of hyaluronic acid was responsible.

Sources:

  • Randomized, Placebo-controlled Study of a Nutraceutical Based on Hyaluronic Acid, L-carnosine, and Methylsulfonylmethane in Facial Skin Aesthetics and Well-being. J Clin Aesthet Dermatol. 2019; 12(4):40-45.
  • Skin Anti-aging and Systemic Redox Effects of Supplementation with Marine Collagen Peptides and Plant-Derived Antioxidants: A Single-Blind Case-Control Clinical Study. Oxid Med Cell Longev. 2016; 2016:4389410.
  • Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2018; 10(7): 826.
  • Oral Intake of Collagen Peptide Attenuates Ultraviolet B Irradiation-Induced Skin Dehydration In Vivo by Regulating Hyaluronic Acid Synthesis. Int J Mol Sci. 2018; 19(11). pii: E3551.

According to a Chinese study of deep-sea fish collagen peptides derived from supporting the treatment of diabetes and high blood pressure. During the 3-month experiment, insulin sensitivity index of collagen users increased, total blood cholesterol and ‘bad’’ cholesterol (low-density lipoprotein) decreased, blood pressure decreased as well as the creatinine level that concluded in improved renal function.

Source:

  • Therapeutic effects of marine collagen peptides on Chinese patients with type 2 diabetes mellitus and primary hypertension. Am J Med Sci. 2010; 340(5):360-6.

Dry eyes are a modern-day folk disease that can lead to eye inflammation or even visual impairment. According to a Korean clinical study, regular intake of hyaluronic acid reduced the symptoms of dry eye syndrome, subjects reported relief of eye irritation, and studies confirmed regeneration of the cornea of the eye.

Source:

  • Oral Hyaluronic Acid Supplementation for the Treatment of Dry Eye Disease: A Pilot Study. J Ophthalmol. 2019; 2019:5491626.

Hyaluron+Collagen

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Science
Ingredients
  • Active Ingredients
  • Ingredients
Active ingredients in a daily dose3 capsules9 capsules
Collagen1332 mg3996 mg
Hyaluronic acid 90%30 mg90 mg
Vitamin C60 mg180 mg
Total polyphenol4,5 mg13,5 mg
of which  
- flavonoid3,15 mg9,45 mg
- resveratrol0,00225 mg0,0067 mg

Collagen from salmon skin, gelatin, bioflavonoid complex (red grape seed and peel, sorghum seed and peel, blackberry seed and peel, black cherry peel, blackcurrant seed and peel, redcurrant seed and peel, plum peel, apple peel), hyaluronic acid (90%), ascorbic acid (Vitamin C).

Dosage

Suggested dose

2-3 capsules daily after meals.
Kiszerelés

Packaging

Packaging

100 capsules
Eltarthatóság

Shelf life

Best before

For 3 years from production. The date of manufacture and expiry are indicated on the packaging.
Tárolás

Storage

Storage

Avoid direct sunlight; in a dry, cool place.
Notice

Daily dose should not be exceeded!

- Drink fair amount of water!
- Dietary supplements are not substitutes for a balanced diet.
- Dietary supplements are not medicines, nor substitutes for medicines!
- Keep out of the reach of children.
- Do not take during pregnancy or in case of high liver enzyme levels!

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