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Herb Selection with chromium

Stemax SL

STEMAX SL (Sugar-low) products contain dried hemp seed, sorghum grain, lingzhi mushroom, spirulina algae, brown algae fucoidan extract and other special herbs, fruits and valuable ingredients, with additional chromium trace elements.

76.200Ft

(168 €)

Availability: Készleten

Stem Cell Therapy - Regenerative Medicine

Stem cell therapy, also known as regenerative medicine, is currently one of the most intensively researched fields. Its application promises solutions that can overcome some diseases that have been considered incurable, and therefore receive more and more attention.

Most stem cell therapies used today use stem cells proliferated outside the body (exogenously formed stem cells) e.g. for diseases associated with chronic inflammation. The exogenous methods are expensive and cannot be considered completely safe, because keeping the cells in a culture outside of the body holds the potential of stem cell mutations, and ingested in the body, unwanted immune responses, or differentiation (different as planned) may occur.

Another trend is to increase the body's ability to regenerate by stimulating and mobilizing (endogenously formed) stem cells within the body without having to isolate and maintain the stem cells under laboratory conditions, making it safer to use.

What are stem cells?

Stem cells can be divided into 2 main types: 1) embryonic stem cells, which have high pluripotency, so they can transform (differentiate) into almost any cell, and 2) adult or somatic stem cells, which have a lower pluripotency and are generally considered to be progenitor cells of that tissue they can be found. In terms of function, adult stem cells are responsible for the maintenance and regeneration of specific tissues, and for the replenishment of damaged and dead cells.

Stem cells are actually everywhere in our body to ensure rapid and efficient tissue regeneration. There are types of stem cells that stay in the tissues throughout, while other stem cells circulate in the body. The latter are located most of the time in the bone marrow, some of which enters the bloodstream and then either return to the bone marrow or enter to the tissues from the circulation, where they can typically return after a few days to the bloodstream through the lymphatics. They can also get back to the bone marrow from the blood, or back to the tissues, and the cycle starts all over again.

This intra-organizational circulation is mostly the characteristic of hematopoietic stem cells (stem cells giving rise to elements of the blood and immune system), but mesenchymal stem cells (MSC, especially cartilage, fat, bone-type differentiation, but can differentiate to muscle and even neuronal direction) and endothelial progenitor cells (vascular progenitor cells) may also circulate in the blood.

Stem cells circulating in the body can enter the tissues with stimuli that remain in place and differentiate into target cells. This can happen e.g. at the site of an infection where hematopoietic stem cells are often converted to immune cells to take up the fight against pathogens. Because only a small portion of stem cells circulate normally in the bloodstream, certain stimulus may increase the number of stem cells entering the bloodstream from the bone marrow. This occurs when the body is exposed to an effect where tissue damage (may) occurs and the regenerative potential of stem cells is required.

Due to the aging process, adverse environmental effects, and unfavorable eating and lifestyle habits, the number of circulating stem cells can decrease over time, which negatively affects our body’s regeneration abilities. In such cases, the so-called stem cell mobilizers are necessary.

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stem cell solo
stem cell solo
stem cell solo
Science behind

Tissue regeneration by stimulation of stem cells

Plant alternatives to stem cell mobilizing factors, which help a greater proportion of stem cells to leave the bone marrow into the bloodstream, are also known, according to recent research. In addition to mobilization, some of them presumably support the self-renewal and division of stem cells, thereby supporting the regeneration of the organism.

One of the potentials of uses for stimulation and mobilization of stem cells is to fight anemia, which often develops e.g. as a result of chemotherapy.

One study examined the effects of the active ingredients of astragalus and angelica (ferulic acid, flavonoids, astragaloside) in mice treated with the chemotherapeutic agent cyclophosphamide. The result of cyclophosphamide the number of red blood cells, platelets and white blood cell, the hemoglobin level drastically decreased, and the area responsible for hematopoiesis in the bone marrow shrunk. The above-listed active ingredients from the herbs also improved the blood count individually, however their combination improved all of the studied parameters and showed values slightly distinct from the pre-treatment condition.

Examined from a mechanistic point of view, the herbal combination (and the individual active agents in varying degrees) also stimulated the self-renewal and proliferation of hematopoietic stem cells, which contributed to rapid regeneration and reversal of treatment-induced stem cell aging.

There is also a study of the lingzhi mushroom in the professional literature that has counteracted the detrimental hematopoietic effects of a chemotherapeutic agent called cyclophosphamide or vinerolbin in animal experiments. Not only chemotherapeutic agents, heavy metals can also damage the bone marrow. The spirulina algae consumption was able to prevent blood count deterioration due to lead or cadmium poisoning in rats.

Sources:

  • Five Active Components Compatibility of Astragali Radix and Angelicae Sinensis Radix Protect Hematopoietic Function Against Cyclophosphamide-Induced Injury in Mice and t-BHP-Induced Injury in HSCs. Front Pharmacol. 2019; 10:936.
  • Effect of recombinant Ganoderma lucidum immunoregulatory protein on cyclophosphamide-induced leukopenia in mice. Immunopharmacol Immunotoxicol. 2013; 35(3):426-33.
  • Screening Immunoactive Compounds of Ganoderma lucidum Spores by Mass Spectrometry Molecular Networking Combined With in vivo Zebrafish Assays. Front Pharmacol. 2020; 11:287.
  • Spirulina platensis feeding inhibited the anemia- and leucopenia-induced lead and cadmium in rats. J Hazard Mater. 2009; 164(2-3):1304-9.

When the cerebral blood vessels become blocked, a state of oxygen deficiency, called ischemic stroke may occur. When the blockage is removed, fresh, oxygen-rich blood flows into the tissues, which can unfortunately often further destroy the already damaged brain cells, this is called ischemic/reperfusion injury. When a stroke occurs, the prompt intervention is very important so that neuronal death occurs in as small an area of the brain as possible.

Many herbal ingredients are known to help repair the damaged condition that develops during stroke and subsequent reperfusion. Primarily, as antioxidants, they protect neurons and tissue stem cells from reactive oxygen-radicals, which is caused by oxidative stress from re-supplying oxygen to the damaged brain area. In addition, a number of plant agents have been shown to be able to stimulate neural progenitors, so they can stimulate neural stem cells to divide and neurogenesis, thus improving brain regeneration and supporting recovery.

Such herbal agents are astragalosides of astragalus root, proanthocyanidins in grape seeds, fucoidan from brown algae, but the consumption of spirulina algae or the linghzi mushroom is also a beneficial effect resulted in animal studies. The mitigation of ischemic/reperfusion damage may be supported by vitamin E, coenzyme Q10 and the rutin flavonoid found in red grape skin, reducing the deteriorating effect of oxidative stress and pro-inflammatory cytokines.

Sources:

  • Astragaloside IV Exerts Cognitive Benefits and Promotes Hippocampal Neurogenesis in Stroke Mice by Downregulating Interleukin-17 Expression via Wnt Pathway. Front Pharmacol. 2020; 11:421.
  • Astragaloside VI Promotes Neural Stem Cell Proliferation and Enhances Neurological Function Recovery in Transient Cerebral Ischemic Injury via Activating EGFR/MAPK Signaling Cascades. Mol Neurobiol. 2019; 56(4):3053-3067.
  • Neuroprotective effect of pretreatment with Ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus. Neural Regen Res. 2014; 9(15):1446-52.
  • Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation. Phytochemistry. 2015; 114:155-62.
  • Grape seed proanthocyanidins attenuate apoptosis in ischemic stroke. Acta Neurol Belg. 2019; doi: 10.1007/s13760-019-01111-9.
  • Neuroprotective effect of Spirulina in cerebral ischemia-reperfusion injury in rats. J Neural Transm (Vienna). 2010; 117(9):1083-91.
  • Leukocyte-platelet aggregates in rat peripheral blood after ischemic stroke and reperfusion. Biol Res Nurs. 2005; 6(4):281-8.
  • Possible role of vitamin E, coenzyme Q10 and rutin in protection against cerebral ischemia/reperfusion injury in irradiated rats. Int J Radiat Biol. 2010; 86(12):1070-8.

A 2-es típusú diabéteszre emelkedett oxidatív stressz szint jellemző, ami a szívben található őssejtek és elődsejtek károsodásával járhat. A szívizomsejtek keletkezésében és regenerációjában fellépő egyensúlyhiány kardiomiopátiához vezethet, ami a szív pumpafunkciójának gyengülését jelenti.

Az astragalus not only successfully inhibited the damage of cardiac stem cells and progenitorsin an artificial diabetic mouse model, but also enhanced the proliferation of these cells, thus their number increased due to the treatment. Moreover, the level of oxidative stress decreased, precluding further cellular damage.

According to a publication reviewing 25 clinical studies, chromium consumption (either alone or combined with vitamins) helped stabilizing the blood glucose level. Emellett a cukorbetegekre jellemző magas triglicerid szintet is több esetben csökkentette.

Ugyan erre jutottak 84 tudományos cikk összefoglalásaként más kutatók is, akik 2010 január és 2018 december közötti klinikai tanulmányokat összegezték. A króm szedése javított a glikémiás indexen, segítette a sejtek glükóz felvételét, és a magas vércukorszint szövődményeire is pozitív hatással volt. A triglicerid szint és az össz. koleszterinszint is csökkent a napi króm bevitel hatására.

Sources:

  • Astragalus polysaccharides protect cardiac stem and progenitor cells by the inhibition of oxidative stress-mediated apoptosis in diabetic hearts. Drug Des Devel Ther. 2018; 12: 943–954.
  • Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes. J Clin Pharm Ther. 2014; 39(3):292-306.
  • Chromium Supplementation; Negotiation with Diabetes Mellitus, Hyperlipidemia and Depression. J Diabetes Metab Disord. 2020; 19(1):585-59.
  • Anemia - Chemotherapy
  • Stroke
  • Type 2 Diabetes

One of the potentials of uses for stimulation and mobilization of stem cells is to fight anemia, which often develops e.g. as a result of chemotherapy.

One study examined the effects of the active ingredients of astragalus and angelica (ferulic acid, flavonoids, astragaloside) in mice treated with the chemotherapeutic agent cyclophosphamide. The result of cyclophosphamide the number of red blood cells, platelets and white blood cell, the hemoglobin level drastically decreased, and the area responsible for hematopoiesis in the bone marrow shrunk. The above-listed active ingredients from the herbs also improved the blood count individually, however their combination improved all of the studied parameters and showed values slightly distinct from the pre-treatment condition.

Examined from a mechanistic point of view, the herbal combination (and the individual active agents in varying degrees) also stimulated the self-renewal and proliferation of hematopoietic stem cells, which contributed to rapid regeneration and reversal of treatment-induced stem cell aging.

There is also a study of the lingzhi mushroom in the professional literature that has counteracted the detrimental hematopoietic effects of a chemotherapeutic agent called cyclophosphamide or vinerolbin in animal experiments. Not only chemotherapeutic agents, heavy metals can also damage the bone marrow. The spirulina algae consumption was able to prevent blood count deterioration due to lead or cadmium poisoning in rats.

Sources:

  • Five Active Components Compatibility of Astragali Radix and Angelicae Sinensis Radix Protect Hematopoietic Function Against Cyclophosphamide-Induced Injury in Mice and t-BHP-Induced Injury in HSCs. Front Pharmacol. 2019; 10:936.
  • Effect of recombinant Ganoderma lucidum immunoregulatory protein on cyclophosphamide-induced leukopenia in mice. Immunopharmacol Immunotoxicol. 2013; 35(3):426-33.
  • Screening Immunoactive Compounds of Ganoderma lucidum Spores by Mass Spectrometry Molecular Networking Combined With in vivo Zebrafish Assays. Front Pharmacol. 2020; 11:287.
  • Spirulina platensis feeding inhibited the anemia- and leucopenia-induced lead and cadmium in rats. J Hazard Mater. 2009; 164(2-3):1304-9.

When the cerebral blood vessels become blocked, a state of oxygen deficiency, called ischemic stroke may occur. When the blockage is removed, fresh, oxygen-rich blood flows into the tissues, which can unfortunately often further destroy the already damaged brain cells, this is called ischemic/reperfusion injury. When a stroke occurs, the prompt intervention is very important so that neuronal death occurs in as small an area of the brain as possible.

Many herbal ingredients are known to help repair the damaged condition that develops during stroke and subsequent reperfusion. Primarily, as antioxidants, they protect neurons and tissue stem cells from reactive oxygen-radicals, which is caused by oxidative stress from re-supplying oxygen to the damaged brain area. In addition, a number of plant agents have been shown to be able to stimulate neural progenitors, so they can stimulate neural stem cells to divide and neurogenesis, thus improving brain regeneration and supporting recovery.

Such herbal agents are astragalosides of astragalus root, proanthocyanidins in grape seeds, fucoidan from brown algae, but the consumption of spirulina algae or the linghzi mushroom is also a beneficial effect resulted in animal studies. The mitigation of ischemic/reperfusion damage may be supported by vitamin E, coenzyme Q10 and the rutin flavonoid found in red grape skin, reducing the deteriorating effect of oxidative stress and pro-inflammatory cytokines.

Sources:

  • Astragaloside IV Exerts Cognitive Benefits and Promotes Hippocampal Neurogenesis in Stroke Mice by Downregulating Interleukin-17 Expression via Wnt Pathway. Front Pharmacol. 2020; 11:421.
  • Astragaloside VI Promotes Neural Stem Cell Proliferation and Enhances Neurological Function Recovery in Transient Cerebral Ischemic Injury via Activating EGFR/MAPK Signaling Cascades. Mol Neurobiol. 2019; 56(4):3053-3067.
  • Neuroprotective effect of pretreatment with Ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus. Neural Regen Res. 2014; 9(15):1446-52.
  • Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation. Phytochemistry. 2015; 114:155-62.
  • Grape seed proanthocyanidins attenuate apoptosis in ischemic stroke. Acta Neurol Belg. 2019; doi: 10.1007/s13760-019-01111-9.
  • Neuroprotective effect of Spirulina in cerebral ischemia-reperfusion injury in rats. J Neural Transm (Vienna). 2010; 117(9):1083-91.
  • Leukocyte-platelet aggregates in rat peripheral blood after ischemic stroke and reperfusion. Biol Res Nurs. 2005; 6(4):281-8.
  • Possible role of vitamin E, coenzyme Q10 and rutin in protection against cerebral ischemia/reperfusion injury in irradiated rats. Int J Radiat Biol. 2010; 86(12):1070-8.

A 2-es típusú diabéteszre emelkedett oxidatív stressz szint jellemző, ami a szívben található őssejtek és elődsejtek károsodásával járhat. A szívizomsejtek keletkezésében és regenerációjában fellépő egyensúlyhiány kardiomiopátiához vezethet, ami a szív pumpafunkciójának gyengülését jelenti.

Az astragalus not only successfully inhibited the damage of cardiac stem cells and progenitorsin an artificial diabetic mouse model, but also enhanced the proliferation of these cells, thus their number increased due to the treatment. Moreover, the level of oxidative stress decreased, precluding further cellular damage.

According to a publication reviewing 25 clinical studies, chromium consumption (either alone or combined with vitamins) helped stabilizing the blood glucose level. Emellett a cukorbetegekre jellemző magas triglicerid szintet is több esetben csökkentette.

Ugyan erre jutottak 84 tudományos cikk összefoglalásaként más kutatók is, akik 2010 január és 2018 december közötti klinikai tanulmányokat összegezték. A króm szedése javított a glikémiás indexen, segítette a sejtek glükóz felvételét, és a magas vércukorszint szövődményeire is pozitív hatással volt. A triglicerid szint és az össz. koleszterinszint is csökkent a napi króm bevitel hatására.

Sources:

  • Astragalus polysaccharides protect cardiac stem and progenitor cells by the inhibition of oxidative stress-mediated apoptosis in diabetic hearts. Drug Des Devel Ther. 2018; 12: 943–954.
  • Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes. J Clin Pharm Ther. 2014; 39(3):292-306.
  • Chromium Supplementation; Negotiation with Diabetes Mellitus, Hyperlipidemia and Depression. J Diabetes Metab Disord. 2020; 19(1):585-59.

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Ingredients
  • Active Ingredients
  • Ingredients
Active ingredients in a daily dose1 capsule2 capsules4 capsules6 capsules
Hempseed60,9 mg121,8 mg243,6 mg365,4 mg
Ganoderma lucidum25 mg50 mg100 mg150 mg
L-carnitine35 mg70 mg140 mg210 mg
L-arginine1,6 mg3,2 mg6,4 mg9,6 mg
Co-enzyme Q102,5 mg5 mg10 mg15 mg
NADH2,5 mg5 mg10 mg15 mg
Astragalus root25 mg50 mg100 mg150 mg
of which astragalosids0,125 mg0,25 mg0,5 mg0,75 mg
Chromium10 μg20 μg40 μg60 μg
*NRV 25%*NRV 50%*NRV 100%*NRV 150%
Total polyphenol8,31 mg16,62 mg33,24 mg49,86 mg
of which flavonoids5,8 mg11,6 mg23,2 mg34,8 mg

*NRV: nutrient reference value for adults

Gelatine, Dried red grape seed-carapace, Inulin, Dried Sorghum seed-carapace, Dried Hempseed, L-Carnitine, Dried Ganoderma Lucidum, Astragalus root extract (Radix Astragali), Q10 co-enzyme (10%), Spirulina algae powder, Chlorophyll, Dried Wolfberry fruit, Dried Blackberry seed-carapace, Cinnamon, Dried Fucoidan grist (brown algae extract), Dried Black Cherry seed-carapace, Dried Blackcurrant seed-carapace, Dried Redcurrant seed-carapace, NADH, Dried Plum carapace, Dried Apple carapace, L-Arginine, Choromium III. Chloride VI. Hyrate. Coloring: Titanium-dioxide, Indigotine.

Dosage

Suggested dose

2 capsules daily after meals; 2x2 or 2x3 capsules per day if requested.
Kiszerelés

Packaging

Packaging

120 kapszula
Eltarthatóság

Shelf life

Best before

For 3 years from production. The date of manufacture and expiry are indicated on the packaging.
Tárolás

Storage

Storage

Avoid direct sunlight; in a dry, cool place.
Notice

Daily dose should not be exceeded!

- Drink fair amount of water!
- Dietary supplements are not substitutes for a balanced diet.
- Dietary supplements are not medicines, nor substitutes for medicines!
- Keep out of the reach of children.
- People with high blood pressure should consult with your physician
- Patients with lymphoma should consult with your physician
- Do not use the product for 24 hours before and after chemotherapy!

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Sea buckthorn as stem cell mobilizer

The sea buckthorn berry is an increasingly popular fruit, which is full of antioxidants. Its wide-scale beneficial effects are known since ancient times. Based on the results of modern science, new scopes have emerged, and it seems that by sea buckthorn, our health can be boosted even more through the exploitation of the regenerative potential of the stem cells within our body.

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Flavita®

Bioflavonoid Complex

Flavita Family

Products of our FLAVITA product family contain concentrated flavonoids and other valuable plant antioxidants in the form of capsules or syrups.