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Tibetan caterpillar fungus

CorsyMAX 10x

The CorsyMAX® 10X is an extract of mycelium (fungal filaments) grown from the spores of Cordyceps sinensis (Chinese caterpillar fungus) from Tibet, combined with flavonoid ingredients.

15.240Ft25.400Ft

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The Chinese caterpillar fungus (Cordyceps sinensis)
An ancient remedy for modern man

According to the experience of Tibetans, the fungus Cordyceps sinensis grows “in the caterpillar in winter, in the grass in summer”.

As can be guessed, the Cordyceps fungus has 2 main life cycles. Its spores attack the caterpillars, in which it lives as a parasite in winter, and then, after the fungus has consumed the nutrients found in the insect, it grows a fruiting body in the summer. In nature, this fungal species grows only in three regions of the Himalayas - Tibet, Nepal and Bhutan - at altitudes above 3000 meters.

The beneficial effects of the Chinese caterpillar fungus have been noticed by Tibetan shepherds for more than two thousand years, hence the name Tibetan caterpillar fungus. These areas of the Himalayas have rarer air and poorer vegetation, so yaks grazed on pastures, or the large domestic animals of Tibetans, should have been more tired.

Nevertheless, the animals grazed here were full of energy compared to their counterparts on the lower-lying pasture, and their desire to reproduce was also higher. The yellowish-brown formation, the caterpillar fungus, which grows between the grass, so is consumed with it, was responsible for this effect.

Based on the above story, it is not surprising that Tibetan Cordyceps sinensis is one of the most valuable ingredients in traditional Chinese medicine. According to legend, for a while, only the emperor could use it to maintain his youth and fertility, to improve his endurance and physiological functions.

Modern medicine and research noticed Tibetan Cordyceps when Chinese athletes who won a gold medal at the Stuttgart World Championships in Athletics stated that they consumed Cordyceps mushrooms to increase their performance. We now know that Tibetan Cordyceps has special healing ingredients, e.g. cordycepinsnot found in other species, it also contains adenosine and rare N- polysaccharides, as well as beta-glucan.

Tibetan Cordyceps is a rare but valuable fungus, in natural occurrence it’s available at a price of $ 20,000 to $ 80,000 /kg, which puts it at risk of over-harvesting and disappearing from its natural habitat. Fortunately, Tibetan caterpillars can now be grown, the advantage of which is that the process takes place under standardized, controlled conditions, making it possible to obtain products with many times higher active ingredients at a much lower cost than the original price.

Things to consider when choosing products:

  1. how much (mg) fungus is contained in one capsule and the recommended daily intake;
  2. the product is a dried ground preparation or an extract of the fungus richer in active ingredients;
  3. manufacturer: whether the product is manufactured in a country with an appropriate quality assurance system;
  4. whether there are other ingredients in the capsule that can stimulate the absorption of the active components and enhance their beneficial effect.
Cordyceps sinensis életciklus
plant island
butterfly
Science behind

Observed effects of the medicinal fungus, Cordyceps sinensis

Folk observations that the caterpillar fungus has an energizing effect on both animals (e.g. yaks) and humans in general, and is a supporter of a longer, healthier life, have now been supported by scientifically demanding experiments.

In addition to improving vitality, a number of previously lesser known beneficial effects have also been identified, e.g. immunomodulatory or anti-cancer activity, which are briefly listed below with examples.

Futhermore scientific researches proves the Cordyceps efficiency in cancer therapy (article).

Increase of vitality, endurance

One of the most common goals of consuming caterpillar fungus is to reduce fatigue and, in parallel, regain vitality. According to a Chinese study, nearly 90% of older people in the experiment reported an improvement in their physical fitness as a result of taking Cordyceps sinensis extract.

The increase in endurance was also supported by a Japanese and an Italian study. In the former, young men performed intense running exercises, and if caterpillar extract was consumed, it was easier to take exerting sports. In the latter, the combined use of caterpillar and lingzhi mushroom has increased the physical fitness of amateur cyclists and made their bodies more prepared for oxidative stress.

The energizing effect has also been tested on animals because the studies can be standardized much better. As an example, experimental mice significantly improved their swimming endurance by supplementing their diet with an extract of caterpillar decoction.

Sources::

  • The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med. 1998; 4(3):289-303.
  • Supplemental Anti-Fatigue effects of Cordyceps sinensis (Tochu-Kaso) extract powder during three stepwise exercise of human. Japanese J. Phys. Fit. Sports Med. 2006; 55:145-152.
  • Improving Training Condition Assessment in Endurance Cyclists: Effects of Ganoderma lucidum and Ophiocordyceps sinensis Dietary Supplementation. Evid Based Complement Alternat Med. 2014; 2014: 979613.
  • Antifatigue and antistress effect of the Hot-water fraction from mycelia of cordyceps sinensis. Biol Pharm Bull. 2003; 26(5):691-4.
Slowing aging...

Cordyceps sinensis has long been attributed to its anti-aging effect. In the case of fruit (vinegar) flies, feeding with caterpillar extract was able to increase the lifespan up to 32%. In the case of mice, in order to keep an experiment from lasting for so many years, accelerated aging models are used when the animals begin to show symptoms of aging within a few months due to continuous consumption of D-galactose, e.g. cognitive (brain) functions began to decline. An extract of Cordyceps sinensis was able to counteract the cognitive decline of D-galactose of aging mice and improve their memory.

Sources:

  • Cordyceps sinensis oral liquid prolongs the lifespan of the fruit fly, Drosophila melanogaster, by inhibiting oxidative stress. Int J Mol Med. 2015; 36(4):939-46.
  • Antiaging effect of Cordyceps sinensis extract. Phytother Res. 2009; 23(1):116-22.

Cardiovascular diseases are among the leading causes of death, so it is particularly important to have our cholesterol and blood fat levels within the appropriate range in order to reduce the risk of arteriosclerosis. The caterpillar extract in mice was able to counteract the harmful effects of a cholesterol-rich diet by helping to keep low-density lipoprotein (“bad” cholesterol) levels low and elevated high-density lipoprotein (“good” cholesterol) levels compared to animals not consuming Cordyceps. The beneficial effects for blood triglycerides and cholesterol could be observed in humans as well, even for pre-existing cardiovascular disorders.

Sources:

  • Hypocholesterolemic effect of hot-water extract from mycelia of Cordyceps sinensis. Biol Pharm Bull. 2003; 26(1):84-7.
  • The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med. 1998; 4(3):289-303.

The caterpillar extract showed an antidepressant-like effect in various mouse experiments, which was also associated with its hypoglycemic and energizing effects.

Sources:

  • Antidepressant-like effect of Cordyceps sinensis in the mouse tail suspension test. Biol Pharm Bull. 2007; 30(9):1758-62.
  • Enhancement of Neuromuscular Activity by Natural Specimens and Cultured Mycelia of Cordyceps sinensis in Mice. Indian J Pharm Sci. 2014; 76(5):458-61.
Enhanced protection against Pathogens

Folk observations show that caterpillar consumers are less likely to get sick and get infections. This is supported by a number of animal experiments, e.g. the survival rate of Streptococcus bacterial infection, which is also dangerous to humans, was significantly increased in mice given Cordyceps extract, but also found a positive effect in the treatment of tuberculosis.

In another case, an active ingredient called cordycepin, which was initially present in small amounts in caterpillars but accounted for up to 1% of Cordyceps extracts, was shown to significantly increase the survival rate of mice in case of Candida infection when treatment with antifungal agents was supported with cordycepin, even when the animals have already been infected with a more drug-resistant strain. Cordycepin may also affect viruses, e.g. directly inhibited adenovirus replication by blocking RNA synthesis.

Influencing the function of the immune system (immune modulation) involves regulating the production of certain cytokines and can also have a stimulating effect on the cellular elements of the immune system.

Sources:

  • Cordyceps sinensis mycelium protects mice from group A streptococcal infection. J Med Microbiol. 2005; 54(Pt 8):795-802.
  • Cordyceps sinensis promotes immune regulation and enhances bacteriostatic activity of PA-824 via IL-10 in Mycobacterium tuberculosis disease. Braz J Med Biol Res. 2017; 50(9):e6188.
  • Antifungal activity of 3′-deoxyadenosine (cordycepin). Antimicrob Agents Chemother. 1998; 42(6): 1424–1427.
  • Differential inhibition of the in vivo synthesis of adenovirus type 5-specific ribonucleic acids by cordycepin. Virology. 1975; 65(1):238-47.

The caterpillar fungus is believed, when consumed on a regular basis, to increase sexual performance, which is why some also call it the Himalayan Viagra. It resulted in higher sperm counts and sperm viability in mice, and the effect of the active substance cordycepin in older rats resulted in the production of more motile sperm similar characteristics to their younger counterparts while increasing their testosterone levels.

There are only a few studies available in the clinic, however, these have consistently found that caterpillar fungus preparations increase sperm quality, thus male fertility, and may increase libido in both men and women.

Sources::

  • Substitution of cordyceps cephalosporium mycelia for cordyceps sinensis in the prescription of Shengjing Capsules: Enhanced effect on spermatogenesis impairment. Zhonghua Nan Ke Xue. 2018; 24(7):627-634.
  • Cordycepin, an Active Constituent of Nutrient Powerhouse and Potential Medicinal Mushroom Cordyceps militaris Linn., Ameliorates Age-Related Testicular Dysfunction in Rats. Nutrients. 2019; 11(4). pii: E906.
  • The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med. 1998; 4(3):289-303.

One of the roles of antioxidants in our body is to neutralize free radicals. The extract of Cordyceps sinensis was able to directly neutralize several free radical forms and inhibited one of the factors in the development of atherosclerosis, lipid peroxidation. In addition, strains extracted from a caterpillar polysaccharide enhanced the functioning of antioxidant enzymes in the liver, brain and blood serum of mice also further increase the antioxidant capacity. A similar conclusion was reached in human experiments, similar to mice, there was an increase in the so-called superoxide dismutase enzyme activity and thus the free radical neutralizing ability.

Sources:

  • Antioxidant activity of the extracts from fruiting bodies of cultured Cordyceps sinensis. Phytother Res. 2000; 14(8):647-9.
  • Morphological and genetic characterization of a cultivated Cordyceps sinensis fungus and its polysaccharide component possessing antioxidant property in H22 tumor-bearing mice. Life Sci. 2006; 78(23):2742-8.
  • The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med. 1998; 4(3):289-303.
Asthma, arthritis

Cordyceps sinensis extracts, especially cordycepin, have been attributed anti-inflammatory effects. Based on its effect on human cell lines, it achieves this by inhibiting the production of inflammatory factors on the one hand, and by increasing the levels of anti-inflammatory interleukins on the other.

Cordycepin alleviated the symptoms of osteoarthritis (inflammation of the arthritis) in animal studies and reduced respiratory hyperresponsiveness associated with asthma, excessive mucus production, and IgE antibody levels. The condition of (human) patients with moderate to severe asthma started to improve, when in addition to the treatment, Cordyceps sinensis was also consumed the level of inflammatory factors and IgE antibody decreased.

Sources:

  • Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi. Molecules. 2019; 24(12) pii: E2231).
  • The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis. Sci Rep. 2019; 9(1):4696.
  • Herbal Medicine Cordyceps sinensis Improves Health-Related Quality of Life in Moderate-to-Severe Asthma. Evid Based Complement Alternat Med. 2016; 2016: 6134593.
Antifibrotic effect

A hernyógomba kivonata képes volt csökkenteni a környezetből származó szennyezők, vagy életmóddal összefüggő káros anyagok roncsoló hatását, védve a veséket, májat és tüdőt. Több, egereken és patkányokon végzett tanulmányban a Cordyceps sinensis csökkentette a májkárosodás mértékét, amikor szén-tetrakloriddal (korábban hűtőanyagként vagy tűzoltásra használt mérgező vegyület) való érintkezésnek tették ki őket. Portugáliában olyan betegeknél tesztelték a Cordyceps sinensist, akiknél rendszeres alkohol fogyasztás következtében májkárosodás (szteatózis, zsírmáj) lépett fel. A gombakészítményt használva gyorsabb volt a máj regenerálódása, mint a sima alkoholmegvonás esetén.

In a renal fibrosis model in rats, the caterpillar fungus successfully inhibited excessive collagen accumulation during renal injury. Cordyceps sinensis also alleviated the severity of induced pulmonary fibrosis in rats through regulation of inflammatory factors.

Sources:

  • Cultured Mycelium Cordyceps sinensis alleviates CCl4-induced liver inflammation and fibrosis in mice by activating hepatic natural killer cells. Acta Pharmacol Sin. 2016; 37(2):204-16.
  • Inhibitive effect of cordyceps sinensis on experimental hepatic fibrosis and its possible mechanism. World J Gastroenterol. 2003; 9(3): 529–533.
  • Cordyceps sinensis Supplementation as Immunonutrition in Alcohol Induced Liver Steatosis-II. Mycology news 2004; 1(9):2-6.
  • Cordyceps sinensis attenuates renal fibrosis and suppresses BAG3 induction in obstructed rat kidney. Am J Transl Res. 2015; 7(5): 932–940.
  • Protective roles of Cordyceps on lung fibrosis in cellular and rat models. J Ethnopharmacol. 2012 Sep 28; 143(2): 448–454.
Reduction of side effects and anti-cancer effect

The caterpillar fungus was able to reduce the destructive effects of certain chemotherapeutic agents (e.g., bleomycin, streptozotocin, cyclophosphamide, cisplatin, vinorelbine, doxorubicin) on healthy cells in mouse, rat, and zebrafish model animals.

In combination with cisplatin, the protective function also had anticancer activity, helping to inhibit the proliferation of tumor cells implanted in both mice and zebrafish. The polysaccharides derived from caterpillar fungus supported the organism of mice undergoing radiotherapy.

The caterpillar fungus formulations have also been tested in the clinic. In a retrospective study, the survival of human patients with hepatocellular carcinoma (malignant liver cancer) was significantly increased when their treatment was supported with preparations containing Cordyceps sinensis. The prognosis of the patients further improved when the C. sinensis was combined with additional products.

Sources:

  • Effectiveness of cultured Cordyceps sinensis combined with glucocorticosteroid on pulmonary fibrosis induced by bleomycin in rats. Zhongguo Zhong Yao Za Zhi. 2011; 36(16):2265-70.
  • The Herbal Medicine Cordyceps sinensis Protects Pancreatic Beta Cells from Streptozotocin-Induced Endoplasmic Reticulum Stress. Can J Diabetes. 2016; 40(4):329-35.
  • Combinatorial usage of fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum ameliorate drug-induced liver injury in mice. Food Chem Toxicol. 2018; 119:66-72.
  • Aqueous extract of Cordyceps sinensis potentiates the antitumor effect of DDP and attenuates therapy-associated toxicity in non-small cell lung cancer via IκBα/NFκB and AKT/MMP2/MMP9 pathways. RSC Adv., 2017; 7:37743-37754.
  • Effect of fermented Cordyceps sinensis on doxorubicin‑induced cardiotoxicity in rats. Mol Med Rep. 2018; 18(3):3229-324.
  • Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to 60Co. Int Immunopharmacol. 2011; 11(12):2251-7.
  • Evidence that naturopathic therapy including Cordyceps sinensis prolongs survival of patients with hepatocellular carcinoma. Integr Cancer Ther. 2013; 12(1):50-68.

Active agents (cordycepin, isoflavonoids) extracted from Cordyceps sinensis slowed the rate of osteoporosis in aging or ovariectomized, estrogen-deficient mice and rats.

Sources:

  • Cordycepin prevents oxidative stress-induced inhibition of osteogenesis. Oncotarget. 2015; 6(34):35496-508.
  • The effects of Cordyceps sinensis phytoestrogen on estrogen deficiency-induced osteoporosis in ovariectomized rats. BMC Complement Altern Med. 2014; 14:484.

The scientific observations, studying the role of caterpillar fungus in supporting the treatment of diabetes is twofold: according to the tests on mice and rats, the fungus or its active ingredient called cordycepin help maintain the normal operation of the kidney after the formation of induced diabetes, and/or may contribute to blood sugar decrease and stabilization (hypoglycemic effect). A summary of human clinical trials suggests that the conclusive evidence of a hypoglycemic effect remains to be seen, but caterpillar fungi have definitely been able to support the treatment of renal impairment.

Sources:

  • Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus. Evid Based Complement Alternat Med. 2012; 2012: 743107.
  • Cordycepin from Cordyceps militaris prevents hyperglycemia in alloxan-induced diabetic mice. Nutr Res. 2015; 35(5):431-9.
  • Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotocin. Am J Chin Med. 2006; 34(5):819-32.
  • Use of Ophiocordyceps sinensis (syn. Cordyceps sinensis) combined with angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) versus ACEI/ARB alone in the treatment of diabetic kidney disease: a meta-analysis. Ren Fail. 2015; 37(4):614-34.
  • Energizing effect
  • Anti-aging effect
  • Cardiovascular protection
  • Antidepressant-like effect
  • Immunomodulation
  • Sexual function support
  • Antioxidant
  • Inflammation reduction
  • Kidney, liver and lung protection
  • Tumors
  • Osteoporosis
  • Diabetes
Increase of vitality, endurance

One of the most common goals of consuming caterpillar fungus is to reduce fatigue and, in parallel, regain vitality. According to a Chinese study, nearly 90% of older people in the experiment reported an improvement in their physical fitness as a result of taking Cordyceps sinensis extract.

The increase in endurance was also supported by a Japanese and an Italian study. In the former, young men performed intense running exercises, and if caterpillar extract was consumed, it was easier to take exerting sports. In the latter, the combined use of caterpillar and lingzhi mushroom has increased the physical fitness of amateur cyclists and made their bodies more prepared for oxidative stress.

The energizing effect has also been tested on animals because the studies can be standardized much better. As an example, experimental mice significantly improved their swimming endurance by supplementing their diet with an extract of caterpillar decoction.

Sources::

  • The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med. 1998; 4(3):289-303.
  • Supplemental Anti-Fatigue effects of Cordyceps sinensis (Tochu-Kaso) extract powder during three stepwise exercise of human. Japanese J. Phys. Fit. Sports Med. 2006; 55:145-152.
  • Improving Training Condition Assessment in Endurance Cyclists: Effects of Ganoderma lucidum and Ophiocordyceps sinensis Dietary Supplementation. Evid Based Complement Alternat Med. 2014; 2014: 979613.
  • Antifatigue and antistress effect of the Hot-water fraction from mycelia of cordyceps sinensis. Biol Pharm Bull. 2003; 26(5):691-4.
Slowing aging...

Cordyceps sinensis has long been attributed to its anti-aging effect. In the case of fruit (vinegar) flies, feeding with caterpillar extract was able to increase the lifespan up to 32%. In the case of mice, in order to keep an experiment from lasting for so many years, accelerated aging models are used when the animals begin to show symptoms of aging within a few months due to continuous consumption of D-galactose, e.g. cognitive (brain) functions began to decline. An extract of Cordyceps sinensis was able to counteract the cognitive decline of D-galactose of aging mice and improve their memory.

Sources:

  • Cordyceps sinensis oral liquid prolongs the lifespan of the fruit fly, Drosophila melanogaster, by inhibiting oxidative stress. Int J Mol Med. 2015; 36(4):939-46.
  • Antiaging effect of Cordyceps sinensis extract. Phytother Res. 2009; 23(1):116-22.

Cardiovascular diseases are among the leading causes of death, so it is particularly important to have our cholesterol and blood fat levels within the appropriate range in order to reduce the risk of arteriosclerosis. The caterpillar extract in mice was able to counteract the harmful effects of a cholesterol-rich diet by helping to keep low-density lipoprotein (“bad” cholesterol) levels low and elevated high-density lipoprotein (“good” cholesterol) levels compared to animals not consuming Cordyceps. The beneficial effects for blood triglycerides and cholesterol could be observed in humans as well, even for pre-existing cardiovascular disorders.

Sources:

  • Hypocholesterolemic effect of hot-water extract from mycelia of Cordyceps sinensis. Biol Pharm Bull. 2003; 26(1):84-7.
  • The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med. 1998; 4(3):289-303.

The caterpillar extract showed an antidepressant-like effect in various mouse experiments, which was also associated with its hypoglycemic and energizing effects.

Sources:

  • Antidepressant-like effect of Cordyceps sinensis in the mouse tail suspension test. Biol Pharm Bull. 2007; 30(9):1758-62.
  • Enhancement of Neuromuscular Activity by Natural Specimens and Cultured Mycelia of Cordyceps sinensis in Mice. Indian J Pharm Sci. 2014; 76(5):458-61.
Enhanced protection against Pathogens

Folk observations show that caterpillar consumers are less likely to get sick and get infections. This is supported by a number of animal experiments, e.g. the survival rate of Streptococcus bacterial infection, which is also dangerous to humans, was significantly increased in mice given Cordyceps extract, but also found a positive effect in the treatment of tuberculosis.

In another case, an active ingredient called cordycepin, which was initially present in small amounts in caterpillars but accounted for up to 1% of Cordyceps extracts, was shown to significantly increase the survival rate of mice in case of Candida infection when treatment with antifungal agents was supported with cordycepin, even when the animals have already been infected with a more drug-resistant strain. Cordycepin may also affect viruses, e.g. directly inhibited adenovirus replication by blocking RNA synthesis.

Influencing the function of the immune system (immune modulation) involves regulating the production of certain cytokines and can also have a stimulating effect on the cellular elements of the immune system.

Sources:

  • Cordyceps sinensis mycelium protects mice from group A streptococcal infection. J Med Microbiol. 2005; 54(Pt 8):795-802.
  • Cordyceps sinensis promotes immune regulation and enhances bacteriostatic activity of PA-824 via IL-10 in Mycobacterium tuberculosis disease. Braz J Med Biol Res. 2017; 50(9):e6188.
  • Antifungal activity of 3′-deoxyadenosine (cordycepin). Antimicrob Agents Chemother. 1998; 42(6): 1424–1427.
  • Differential inhibition of the in vivo synthesis of adenovirus type 5-specific ribonucleic acids by cordycepin. Virology. 1975; 65(1):238-47.

The caterpillar fungus is believed, when consumed on a regular basis, to increase sexual performance, which is why some also call it the Himalayan Viagra. It resulted in higher sperm counts and sperm viability in mice, and the effect of the active substance cordycepin in older rats resulted in the production of more motile sperm similar characteristics to their younger counterparts while increasing their testosterone levels.

There are only a few studies available in the clinic, however, these have consistently found that caterpillar fungus preparations increase sperm quality, thus male fertility, and may increase libido in both men and women.

Sources::

  • Substitution of cordyceps cephalosporium mycelia for cordyceps sinensis in the prescription of Shengjing Capsules: Enhanced effect on spermatogenesis impairment. Zhonghua Nan Ke Xue. 2018; 24(7):627-634.
  • Cordycepin, an Active Constituent of Nutrient Powerhouse and Potential Medicinal Mushroom Cordyceps militaris Linn., Ameliorates Age-Related Testicular Dysfunction in Rats. Nutrients. 2019; 11(4). pii: E906.
  • The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med. 1998; 4(3):289-303.

One of the roles of antioxidants in our body is to neutralize free radicals. The extract of Cordyceps sinensis was able to directly neutralize several free radical forms and inhibited one of the factors in the development of atherosclerosis, lipid peroxidation. In addition, strains extracted from a caterpillar polysaccharide enhanced the functioning of antioxidant enzymes in the liver, brain and blood serum of mice also further increase the antioxidant capacity. A similar conclusion was reached in human experiments, similar to mice, there was an increase in the so-called superoxide dismutase enzyme activity and thus the free radical neutralizing ability.

Sources:

  • Antioxidant activity of the extracts from fruiting bodies of cultured Cordyceps sinensis. Phytother Res. 2000; 14(8):647-9.
  • Morphological and genetic characterization of a cultivated Cordyceps sinensis fungus and its polysaccharide component possessing antioxidant property in H22 tumor-bearing mice. Life Sci. 2006; 78(23):2742-8.
  • The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med. 1998; 4(3):289-303.
Asthma, arthritis

Cordyceps sinensis extracts, especially cordycepin, have been attributed anti-inflammatory effects. Based on its effect on human cell lines, it achieves this by inhibiting the production of inflammatory factors on the one hand, and by increasing the levels of anti-inflammatory interleukins on the other.

Cordycepin alleviated the symptoms of osteoarthritis (inflammation of the arthritis) in animal studies and reduced respiratory hyperresponsiveness associated with asthma, excessive mucus production, and IgE antibody levels. The condition of (human) patients with moderate to severe asthma started to improve, when in addition to the treatment, Cordyceps sinensis was also consumed the level of inflammatory factors and IgE antibody decreased.

Sources:

  • Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi. Molecules. 2019; 24(12) pii: E2231).
  • The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis. Sci Rep. 2019; 9(1):4696.
  • Herbal Medicine Cordyceps sinensis Improves Health-Related Quality of Life in Moderate-to-Severe Asthma. Evid Based Complement Alternat Med. 2016; 2016: 6134593.
Antifibrotic effect

A hernyógomba kivonata képes volt csökkenteni a környezetből származó szennyezők, vagy életmóddal összefüggő káros anyagok roncsoló hatását, védve a veséket, májat és tüdőt. Több, egereken és patkányokon végzett tanulmányban a Cordyceps sinensis csökkentette a májkárosodás mértékét, amikor szén-tetrakloriddal (korábban hűtőanyagként vagy tűzoltásra használt mérgező vegyület) való érintkezésnek tették ki őket. Portugáliában olyan betegeknél tesztelték a Cordyceps sinensist, akiknél rendszeres alkohol fogyasztás következtében májkárosodás (szteatózis, zsírmáj) lépett fel. A gombakészítményt használva gyorsabb volt a máj regenerálódása, mint a sima alkoholmegvonás esetén.

In a renal fibrosis model in rats, the caterpillar fungus successfully inhibited excessive collagen accumulation during renal injury. Cordyceps sinensis also alleviated the severity of induced pulmonary fibrosis in rats through regulation of inflammatory factors.

Sources:

  • Cultured Mycelium Cordyceps sinensis alleviates CCl4-induced liver inflammation and fibrosis in mice by activating hepatic natural killer cells. Acta Pharmacol Sin. 2016; 37(2):204-16.
  • Inhibitive effect of cordyceps sinensis on experimental hepatic fibrosis and its possible mechanism. World J Gastroenterol. 2003; 9(3): 529–533.
  • Cordyceps sinensis Supplementation as Immunonutrition in Alcohol Induced Liver Steatosis-II. Mycology news 2004; 1(9):2-6.
  • Cordyceps sinensis attenuates renal fibrosis and suppresses BAG3 induction in obstructed rat kidney. Am J Transl Res. 2015; 7(5): 932–940.
  • Protective roles of Cordyceps on lung fibrosis in cellular and rat models. J Ethnopharmacol. 2012 Sep 28; 143(2): 448–454.
Reduction of side effects and anti-cancer effect

The caterpillar fungus was able to reduce the destructive effects of certain chemotherapeutic agents (e.g., bleomycin, streptozotocin, cyclophosphamide, cisplatin, vinorelbine, doxorubicin) on healthy cells in mouse, rat, and zebrafish model animals.

In combination with cisplatin, the protective function also had anticancer activity, helping to inhibit the proliferation of tumor cells implanted in both mice and zebrafish. The polysaccharides derived from caterpillar fungus supported the organism of mice undergoing radiotherapy.

The caterpillar fungus formulations have also been tested in the clinic. In a retrospective study, the survival of human patients with hepatocellular carcinoma (malignant liver cancer) was significantly increased when their treatment was supported with preparations containing Cordyceps sinensis. The prognosis of the patients further improved when the C. sinensis was combined with additional products.

Sources:

  • Effectiveness of cultured Cordyceps sinensis combined with glucocorticosteroid on pulmonary fibrosis induced by bleomycin in rats. Zhongguo Zhong Yao Za Zhi. 2011; 36(16):2265-70.
  • The Herbal Medicine Cordyceps sinensis Protects Pancreatic Beta Cells from Streptozotocin-Induced Endoplasmic Reticulum Stress. Can J Diabetes. 2016; 40(4):329-35.
  • Combinatorial usage of fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum ameliorate drug-induced liver injury in mice. Food Chem Toxicol. 2018; 119:66-72.
  • Aqueous extract of Cordyceps sinensis potentiates the antitumor effect of DDP and attenuates therapy-associated toxicity in non-small cell lung cancer via IκBα/NFκB and AKT/MMP2/MMP9 pathways. RSC Adv., 2017; 7:37743-37754.
  • Effect of fermented Cordyceps sinensis on doxorubicin‑induced cardiotoxicity in rats. Mol Med Rep. 2018; 18(3):3229-324.
  • Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to 60Co. Int Immunopharmacol. 2011; 11(12):2251-7.
  • Evidence that naturopathic therapy including Cordyceps sinensis prolongs survival of patients with hepatocellular carcinoma. Integr Cancer Ther. 2013; 12(1):50-68.

Active agents (cordycepin, isoflavonoids) extracted from Cordyceps sinensis slowed the rate of osteoporosis in aging or ovariectomized, estrogen-deficient mice and rats.

Sources:

  • Cordycepin prevents oxidative stress-induced inhibition of osteogenesis. Oncotarget. 2015; 6(34):35496-508.
  • The effects of Cordyceps sinensis phytoestrogen on estrogen deficiency-induced osteoporosis in ovariectomized rats. BMC Complement Altern Med. 2014; 14:484.

The scientific observations, studying the role of caterpillar fungus in supporting the treatment of diabetes is twofold: according to the tests on mice and rats, the fungus or its active ingredient called cordycepin help maintain the normal operation of the kidney after the formation of induced diabetes, and/or may contribute to blood sugar decrease and stabilization (hypoglycemic effect). A summary of human clinical trials suggests that the conclusive evidence of a hypoglycemic effect remains to be seen, but caterpillar fungi have definitely been able to support the treatment of renal impairment.

Sources:

  • Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus. Evid Based Complement Alternat Med. 2012; 2012: 743107.
  • Cordycepin from Cordyceps militaris prevents hyperglycemia in alloxan-induced diabetic mice. Nutr Res. 2015; 35(5):431-9.
  • Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotocin. Am J Chin Med. 2006; 34(5):819-32.
  • Use of Ophiocordyceps sinensis (syn. Cordyceps sinensis) combined with angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) versus ACEI/ARB alone in the treatment of diabetic kidney disease: a meta-analysis. Ren Fail. 2015; 37(4):614-34.

Cordyceps

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Ingredients
  • Active Ingredients
  • Ingredients

CorsyMAX 10x: Cordyceps sinensis extract, Gelatine, dried and milled Kudzu root, Coleus forskohlii extract, Tribulus terrestris leaf extract, L-Arginine-hydrochloride. Coloring: Titanium-dioxide, Yellow iron-oxide, Indigotine.
CorsyMAXCordyceps sinensis extract, Gelatine, Coloring: Titanium-dioxide, Yellow iron-oxide, Indigotine.

Dosage

Suggested dose

Take 2 capsules daily before breakfast or lunch; as required take up to 4-6 capsules daily before breakfast or lunch.
Kiszerelés

Packaging

Packaging

60 capsules /box
Eltarthatóság

Shelf life

Best before

For 3 years from production. The date of manufacture and expiry are indicated on the packaging.
Tárolás

Storage

Storage

Avoid direct sunlight; in a dry, cool place.
Notice

Daily dose should not be exceeded!

- Drink fair amount of water!
- In the case of stomach pain, take it after meal!
– A napi ajánlott mennyiséget ne lépje túl!
- Dietary supplements are not substitutes for a balanced diet.
- Dietary supplements are not medicines, nor substitutes for medicines!
- Keep out of the reach of children.
- Do not use the product for 24 hours before and after chemotherapy!

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